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Chloroacetamidine-based Inhibitors and Activity-based Probes for the Protein Arginine Methyltransferases

Reference #: 00771 Invention Description: The present invention is a potent, irreversible inhibitor, targeting protein arginine methyltransferase 1. Inhibition studies have demonstrated that the inhibitor is a potent and selective inactivator of the enzyme. This inhibitor covalently modifies an active site residue on the enzyme. Potential Applications: This...

Published: 9/1/2022 | Inventor(s): Paul Thompson, Tanesha Osborne, Obiamaka Obianyo, Corey Causey

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Category(s): Chemistry and Biochemistry