Reference #: 00771
Invention Description:
The present invention is a potent, irreversible inhibitor, targeting protein arginine methyltransferase 1. Inhibition studies have demonstrated that the inhibitor is a potent and selective inactivator of the enzyme. This inhibitor covalently modifies an active site residue on the enzyme.
Potential Applications:
This inhibitor could be a vital tool in the treatment of heart and vascular diseases. By regulating the levels of ADMA, NO synthesis can be increased, leading to improved vascular homeostasis. It is also believed that this inhibitor, or a derivative, can be useful in the treatment of breast cancer by helping to control PRMT1, debilitating early developing breast cancer cells.
Advantages and Benefits:
This inhibitor has a potency and selectivity ideal for generating therapeutic agents for the treatment of heart disease and breast cancer.