Specific Gene Polymorphisms in Cancer Disease Diagnosis, Prevention and Treatment

Description:

Reference #: 00687

The University of South Carolina is offering licensing opportunities for a direct nucleotide sequencing strategy that identifies polymorphisms of CD44, which may account for 80% of breast cancer cases.

Potential Applications:

This nucleotide sequencing strategy is used in the prevention, diagnosis, and treatment of breast cancer.

Advantages and Benefits:

  • Aids in the diagnosis of breast cancer at earlier stages leading to higher survivability

  • Identifies CD44 polymorphism which may account for 80% of breast cancer cases

Background:

Currently, two breast cancer susceptibility genes, BRCA1 and BRCA2, account for approximately 15% of breast cancer cases due to inherited mutations or alterations. However, BRCA1 and BRCA2 mutations are present in far less than 1% of the general population. The proportion of breast cancer in the general population explained by these mutations is very small. CD44 polymorphisms, on the other hand, may account for 80% of breast cancer cases. Therefore, a reliable technique for identification of these polymorphisms has great potential in clinical risk assessment, prediction, prevention, diagnosis, and treatment for breast cancer patients.

Invention Description:

This technology is a direct nucleotide sequencing strategy to identify which polymorphisms and their corresponding nucleotide sequence changes have the highest frequencies in breast cancer patients. Polymorphisms of the gene coding for the CD44 cell surface transmembrane glycoprotein have recently been shown to play an important role in breast cancer development, mainly as a result of their interaction with hyaluronan. Therefore, this novel sequencing strategy offers great promise in the prevention, diagnosis, and treatment of cancer.

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Specific Gene Polymorphisms in Cancer Disease Diagnosis, Prevention and Treatment Utility United States 12/555,128 8,367,415 9/8/2009 2/5/2013 7/28/2030  
Specific Gene Polymorphisms in Cancer Disease Diagnosis, Prevention and Treatment Continuation United States 13/735,320 8,476,074 1/7/2013 7/2/2013 9/8/2029  
For Information, Contact:
Technology Commercialization
University of South Carolina
technology@sc.edu
Inventors:
Juhua Zhou
Mitzi Nagarkatti
Prakash Nagarkatti
Keywords:
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