Cortical-Bone-Like Microtubular Laminated Composite Scaffold Composition

Description:
 

Reference #: 01013

The University of South Carolina is offering licensing opportunities for a degradable, cortical-bone-like construct that provides mechanical and nutrient support unlike metallic scaffolds, which remain in the implantation site and may eventually lead to device failure and tissue damage.

Invention Description:

The subject invention describes the composition, synthesis, and assembly of a set of bonded degradable microtubes that mimic the nano- and microstructure of cortical bone.

Potential Applications:

ยท       All products used in orthopedics for fixation and repair of large bone defects

Advantages and Benefits:

In cortical bone, the aligned collagen fibrils are the building blocks of mineralized tissue. Layers of fibrils are laminated to form microtubular osteons with concentric layers of lamellae surrounding a central Haversian canal. The composition used in this application embodies many of the complexities of the native cortical (compact) bone, resulting in a cellular construct with balanced strength to resist tissue deformation and transport of nutrients to the entire scaffold volume.

Background:

The reconstruction of large, load-bearing skeletal defects is a major problem that has not been addressed due to lack of materials that can provide mechanical support and homogenous transfer of nutrients. While autologous bone graft is the current gold standard, limited supply, donor site morbidity, complexity, and cost of the operation are all clinical concerns and obstacles.

Metallic cages have been used to provide strength and reduce scaffold deformation, but their use suffers from long-term complications which may include device failure, tissue damage, premature loosening of the implant, or the formation of bone with inferior quality and resorption volume. Synthetic non-metallic bone grafts have high clinical failure rates attributed to insufficient strength, inhomogeneous production of extracellular matrix (ECM), and limited exchange of nutrients/oxygen in the central part of the implant leading to implant collapse.

Therefore, reconstruction of malunion and nonunion bone segments remains a significant clinical problem. Resorbable tissue engineered grafts have the potential to accelerate reconstruction of bone defects if they are space-occupying, protect the defect from soft tissue-induced deformation, and have interconnected vascular network for uniform transport of nutrients.

Experimental Validation:

Samples of the cortical-bone-like scaffold were synthesized and tested with respect to cell compatibility, mechanical strength, and degradation.

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Biomineralization Promoting Materials and Methods of Forming Same Utility United States 14/260,442 9,314,549 4/24/2014 4/19/2016    
For Information, Contact:
Technology Commercialization
University of South Carolina
technology@sc.edu
Inventors:
Esmaiel Jabbari
Keywords:
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