M13 Bacteriophage as a Chemoaddressable Nanoparticle for Sensing and Cell Culturing

Description:

Reference #: 00749

Invention Description:

The present invention is the use of M13 bacteriophage for cell targeting, cell imaging, drug delivery vehicle, and bio-scaffold able to direct cell growth.

Potential Applications:

Can be customized for various therapeutic applications:

  • bio-imaging (use of fluorescent dyes, magnetic contrast imaging agents)
  • cell targeting molecules (use of boronic acids, folic acid, antibodies)
  • drugs at high local concentrations to increase detection sensitivity and efficacy for therapeutic applications

Advantages and Benefits:

  • Provides a wide array of shapes as rods and spheres
  • Provides variety of sizes spanning from tens to hundreds of nanometers
  • Evolutionary tested
  • Multi-faceted systems with highly ordered spatial arrangement
  • Provide natural cell targeting and genetic information storing
  • Easily fabricated into liquid-crystal like thin films able to direct cell to growth in a well-defined direction
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
M13 Bacteriophage as a Chemoadressable Nanoparticle for Biological and Medical Applications Utility United States 12/604,575 8,415,131 10/23/2009 4/9/2013 5/6/2031  
For Information, Contact:
Technology Commercialization
University of South Carolina
technology@sc.edu
Inventors:
Qian Wang
Charlene Mello
Keywords:
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