Prevention of Osteoarthritis and Other Pathological Calcifications


Reference #: 00698

Title: Prevention of Osteoarthritis and Other Pathological Calcifications

The University of South Carolina is offering licensing opportunities for a technology that advances the study and treatment of osteoarthritis and other pathological calcifications.

Potential Applications:

In addition to the treatment of osteoarthritis, chondrocalcinosis, and atherosclerosis, this technology can have applications in the areas of oncology, inflammation and virology.

Advantages and Benefits:

Provides a fully functional model of the first steps in protein-membrane interaction

Lower toxicity than existing therapies


Osteoarthritis, the most common joint disorder, causes nearly 27 million Americans to suffer pain and stiffness in the joints. The disease carries a high cost due to its prevalence, disabling effects and expensive treatment. New and cost effective treatments are needed to address this costly and common disease.

Invention Description:

This invention is a formulation and method for preventing the de novo mineral formation in pathological calcifications by providing a functional model that represents the first steps in protein-membrane interaction. Furthermore, the invention describes drugs that interfere with this process and that have lower toxicity than existing therapies.

The present invention relates to biological materials and methods of constructing in vitro and in silico representative mineralization models and substances for treating and preventing the onset or reducing the onset potential of future or additional pathological calcification diseases such as osteoarthritis, chondrocalcinosis, and atherosclerosis. Specifically, the present invention relates to the formation of a complex that models how a key protein interacts with lipid bilayers, important in many disease processes.

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Systems and methods for Determination of Compounds for Stimulation or Inhibition of Neocalcification Utility United States 12/266,837 11/7/2008      
For Information, Contact:
Technology Commercialization
University of South Carolina
Brian Genge
Licia Wu
Roy Wuthier
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