A Robust Paradigm for In Vitro Screening and Discovery of Drugs for the Prevention of Osteoarthritis and Pathological Biomineralization and Atherosclerosis


Reference #:  00655


The University of South Carolina is offering licensing opportunities for this technology to expedite the discovery of drugs for the treatment and prevention of osteoarthritis and other diseases related to pathological calcifications.


Invention Description:


This technology presents a new method for a robust mineralization model and precise monitoring process that enables a continual, semi-automated systematic study of calcification in vitro.  The model and assay system of this technology are amenable for use as high-throughput screening and discovery of pathological calcification treatments.  This technology also identifies a key calcium binding protein involved in the mineralization process that synergistically stimulates a potent nucleator of mineral formation.  The components of this technology could also be used as a novel biomaterial to stimulate mineralization in vivo, such as stimulating fracture healing in bones or as bone filler.  Tests of the model and assay accurately, precisely and reliably reproduced mineralization in vitro.  The model yields replicate values that typically agree within 5%. The validity of the monitoring system has been tested in studies comparing formations monitored by this method with control incubations. 


Potential Applications:


In the application of osteoarthritis research, the subject model and assay system may be used for the screening and discovery of drugs to prevent mineralization.  Components identified by this technology may also be used to stimulate mineralization in vivo, facilitating improved fracture healing.


Advantages and Benefits:

This invention is an effective, non-destructive, and reliable method of monitoring and predicting the calcification of tissue in organisms.  Solid phase formation can be monitored precisely and continually without disturbing the targeted system. This technology is also able to accurately predict maximal mineral formation amounts when using a 5-parameter logistic curve fitting algorithm software program.

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Biomimetic Mineralization Method and System Utility United States 12/108,041 4/23/2008      
For Information, Contact:
Technology Commercialization
University of South Carolina
Brian Genge
Licia Wu
Roy Wuthier
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