NEFIG Nano-Electric Field Implanted Generator for Modulating Wound Healing Response


Reference #: 00836

The University of South Carolina is offering licensing opportunities for a device that modulates the body’s wound healing. The nano-electric field implanted generator (NEFIG) can inhibit detrimental responses to cosmetic and biomedical implants.

Invention Description:

The nano-electric field implanted generator for modulating wound healing response (NEFIG) is a revolutionary new approach to modulating the body’s wound healing response. This technology alters and controls the inflammatory wound healing response using an electrical field created in close proximity to the implant. Nano-fabricated electrodes are placed on the interfacial surface between the implant and the body, and the electrodes are energized with an electric field of controlled strength to modulate the wound healing response and inhibit capsule formation. Once the device is inserted and activated, electrical charging and energy management can be done remotely, ensuring a minimal number of subsequent surgeries.

Advantages and Benefits:

  • The device works independently for long periods of time inside the body without wire connections to the outside.

  • On-demand modulation of the electric field strength and electric current intensity can be done through a remote wireless connection.

  • Regenerative energy management and noncontact electrical charging are employed to ensure minimal surgical intervention is required after the NEFIG device is activated.

Potential Applications:

The device can be used to modulate the body’s wound healing response after cosmetic surgery and the implantation of medical devices, such as heart rate monitors, pace makers, and glucose monitors.


The body’s wound healing response, while beneficial in most cases, may be detrimental in several situations. Surgery patients can experience a detrimental wound healing response resulting in inflammation and eventual formation of a hard capsule around implants. For example, implanted biomedical devices like heart rate monitors, pace makers, and glucose monitors are subject to rapid failure due to the wound healing response by humoral and cellular elements. The ultimate result is migration of fibroblasts and production of collagen which walls off the implant from the surrounding biologic tissues. Most attempts at controlling this process and prolonging survival of implanted sensors and devices have relied on chemical inhibition of the inflammatory and wound healing pathways or surface alterations of the implants.

Patent Information:
For Information, Contact:
Technology Commercialization
University of South Carolina
Victor Giurgiutiu
Harold Friedman
Arash Kheradvar
Bin Lin
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