Devitalized Cell Microsheets for Growth Factor Release and Immune Regulation


Reference #: 01242


The University of South Carolina is offering licensing opportunities for using autogenic cells on a substrate as a depot for the release of osteogenic and bone-forming factors.




Complex skeletal injuries, as a result of trauma and resection of primary tumors in the civilian population are a significant clinical problem. More than 50,000 patients with traumatic injuries have massive skeletal defects that require bone grafting and mechanical stabilization to prevent amputation. The current gold standard for bone graft is the autograft bone. It provides a continuous supply of osteogenic and vasculogenic growth factors and cells within an osteoconductive matrix for healing without eliciting an immune response. Allogeneic cadaver bone is used for bone grafting in orthopedic surgery when autograft bone is insufficient. Due to insufficient healing, more than 3% of traumatic injuries lead to amputation. However, allogeneic cells and growth factors that contributes to regeneration and healing have to be removed from allograft to prevent immune response. An innovative method for the automatic prevention of immune response and the activation of regenerative capacities in allogeneic cells is needed.


Invention Description:


Cells in autograft bone eventually die after transplantation. They are not integrated with the regenerated tissue but secrete cytokines that contribute to healing. The subject invention is a mimicry of this process. The new invention uses autogenic, dead, or devitalized cells on a bone-like substrate as a depot for the release of osteogenic and bone-forming factors. The experimental results confirm the idea that autogenic devitalized cells elicit a constructive immune response and continually release osteogenic factors for healing. 


Potential Applications:


1.       Processed allograft can be used for bone grafting when autograft bone is insufficient.

2.       Patients who suffer from low back pain, vertebral fracture and tumors, spinal infection, spinal deformities and degenerative disc disease and need to undergo a spinal fusion surgery will also benefit from this invention.


Advantages and Benefits:


The bone graft based of this invention is expected to transform bone graft technology for regeneration of complex bone defects from allograft to a safe, infection-free, mechanically-stable, osteoinductive, and vasculoinductive graft that is ultimately displaced by the patient’s own tissue.

Patent Information:
For Information, Contact:
Technology Commercialization
University of South Carolina
Esmaiel Jabbari
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