An Automated ISFET-Based Ion Channel Screening System


Reference #:  00998

The University of South Carolina is offering licensing opportunities for the first automated ISFET-based screening system for the acquisition of real-time ion efflux data from cells cultured in multi-well plates.

Invention Description:

The subject invention is an automated ion-sensitive field effect transistor (ISFET) based instrument for ion channel drug screening of cells cultured in multi-well plates. The components of this system allow for simultaneous, real-time measurements and analyses of ion efflux data.

Advantages and Benefits:

ISFET-based sensors have a number of characteristics that make them desirable for designing ion channel screening assays. Their miniature size (<5mm), rapid response time, and large-scale integrative electronic capacity make them ideal for measuring ion concentrations in a number of cell-based assay formats. This technology is the first instrument to automate ion channel analysis in both primary and stem cells.

Potential Applications:

Ion channel drug discovery programs.

Market Highlights/Commercial Opportunity:

Ion channels have become important targets for the development of new therapeutic agents, with modulators of ion flux representing up to 17% of world pharmaceutical sales.1 Cell-based screening assays are now widely used for identifying compounds that serve as ion channel modulators. These assays are expected to comprise 20% of the $79.0 billion global market for drug discovery technologies and products by 2017.2


Patent Information:
For Information, Contact:
Technology Commercialization
University of South Carolina
Kenneth Walsh
Goutam Koley
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